Lack of therapeutic effect after heparin administration?

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Mon, 10/20/2025 - 18:22

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Nicole Lloyd

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Joined: 08/28/2020 - 05:33

Lack of therapeutic effect after heparin administration?

We have had a handful of cases recently reported by our Cardiology teams where ACT levels were not becoming elevated as expected after heparin administration. We have seen 5 reported cases in the last 3 months via our reporting system, however, a couple of reports noted that this situation has happened to them multiple times over the last few months.

The product is Meitheal 10,000 units/10mL mulit-dose vials. The lot number primarily involved is AGC611P. There was one report involving the same brand but with the lot #A6C2412P.

We are reporting to MedWatch and alerting teams, however, just wondering if anyone else has seen any reporting around this issue at their site?

Thank you!